Formulation of rifampicin–cyclodextrin complexes for lung nebulization
نویسندگان
چکیده
منابع مشابه
Formulation of rifampicin-cyclodextrin complexes for lung nebulization.
Lung administration of antibiotics by nebulization is promising for improving treatment efficiency for pulmonary infections, as it increases drug concentration at sites of infection while minimizing systemic side effects. For poorly soluble molecules like rifampicin, cyclodextrins (CD) may improve lung delivery by permitting higher dosing. For this purpose, we investigated rifampicin-CD complex...
متن کاملComparison of lung deposition in two types of nebulization: intrapulmonary percussive ventilation vs jet nebulization.
BACKGROUND So-called intrapulmonary percussive ventilation (IPV), frequently coupled with a nebulizer, is increasingly used as a physiotherapy technique; however, its physiologic and clinical values have not been rigorously assessed. STUDY OBJECTIVE To compare in vitro and in vivo characteristics of the nebulizer of the IPV device (Percussionaire; Percussionaire Corporation; Sandpoint, ID) wi...
متن کاملDevelopment of a liposome-based formulation for vitamin K1 nebulization on the skin
Vitamin K1 (VK1) is a very lipophilic and photosensitive molecule contained in some vegetables. Recently, the use of VK1 on the skin has been proposed for different pharmaceutical or cosmeceutical applications. In this study, an innovative strategy for the administration of VK1 on the skin was proposed. In particular, to overcome the drawbacks associated with a VK1-containing fatty ointment ava...
متن کاملEffect of drug-targeting nebulization on lung delivery.
1. Mickle JE, Macek Jr M, Fulmer-Smentek SB, Egan MM, Schwiebert E, Guggino W, et al. A mutation in the cystic fibrosis transmembrane conductance regulator gene associated with elevated sweat chloride concentrations in the absence of cystic fibrosis. Hum Mol Genet. 1998;7:729–35. 2. Salvatore D, Tomaiuolo R, Vanacore B, Elce A, Castaldo G, Salvatore F. Isolated elevated sweat chloride concentra...
متن کاملstrategies formulation for dairy cattle complexes, using fuzzy ahp group
abstract the objectives of this study were to identify the strengths (s), weaknesses (w), opportunities (o) and threats (t) in producing milk in the province of sistan and baluchestan . furthermore, the study attempted at developing strategies towards effective management of in the milk production. under the current situation, the study data was collected using questionnaires responded by three...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Controlled Release
سال: 2008
ISSN: 0168-3659
DOI: 10.1016/j.jconrel.2008.04.007